Our mission is to provide homeless cats and dogs with the highest quality of life and a dedicated second chance to find a forever family. We believe that every animal deserves a loving, permanent home where they can experience the trust and care they truly deserve.
Founded in 1975, Open Door Animal Sanctuary has grown to become the largest no-kill shelter in the greater St. Louis area and the State of Missouri. For nearly 50 years, we have provided hope, help, and healing to tens of thousands of animals by taking in stray, neglected, and otherwise unwanted cats and dogs.
We are proud to operate a no-kill facility where we provide shelter, nutritious food, and expert medical care to more than 350 animals every single day. Our residents enjoy a largely cage-free living environment, including cozy kennels with climate control and specialized catteries designed to keep them happy and comfortable while they wait for their new families. Beyond the sanctuary, our foster program allows us to provide additional support to animals needing a quiet home to heal or grow.
We believe that adoption is a joyful partnership, which is why our experienced care teams work closely with you to find the right pet for your unique lifestyle. We guide you through the process—from the initial meeting to ensuring a smooth transition into your home—to make sure your new family member is the perfect fit. Our lifetime return policy ensures that every animal who comes through our doors is always guaranteed a safe place to land.
Are you ready to meet your new best friend? We invite you to view our adoptable cats and dogs online or contact us to schedule an adoption appointment. Come visit our sanctuary in House Springs and fall in love with a pet that will change your life forever.